Pruritus and/or fatigue may lead to depression in patients with primary biliary cholangitis (PBC)
- The following symptoms were noted in a Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV), study of patients with PBC and primary sclerosing cholangitis with a Beck Depression Inventory (BDI)a score greater than 101:
- Depressed mood (24%)
- Loss of interest (12%)
- Feelings of worthlessness (9%)
- Suicidal ideation (9%)
- Psychomotor Agitation or retardation (3%)
- In contrast, fatigue (itself a DSM-IV criterion) was present in 71% of patients with a BDI score of 101
- Patients should obtain psychiatric support if they demonstrate depression and/or suicidal intentions2
aA standardized psychiatric questionnaire used in diagnosis of depression.
References: 1. van Os E, van den Broek WW, Mulder PGH, ter Borg PCJ, Bruijn JA, van Buuren HR. Depression in patients with primary biliary cirrhosis and primary sclerosing cholangitis. J Hepatol. 2007;46(6):1099-1103. doi:10.1016/j.jhep.2007.01.036. 2. Michalak A, Hanc M, Fatyga A, Skublewska A, Prystupa A, Mosiewicz J. Pruritus in liver disease—pathenogenisis and treatment. J Pre-Clin Clin Res. 2011;5(2):47-49.